Nature Communications (Oct 2017)
Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain
- Y. Anraku,
- H. Kuwahara,
- Y. Fukusato,
- A. Mizoguchi,
- T. Ishii,
- K. Nitta,
- Y. Matsumoto,
- K. Toh,
- K. Miyata,
- S. Uchida,
- K. Nishina,
- K. Osada,
- K. Itaka,
- N. Nishiyama,
- H. Mizusawa,
- T. Yamasoba,
- T. Yokota,
- K. Kataoka
Affiliations
- Y. Anraku
- Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
- H. Kuwahara
- Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU)
- Y. Fukusato
- Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
- A. Mizoguchi
- Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
- T. Ishii
- Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
- K. Nitta
- Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU)
- Y. Matsumoto
- Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
- K. Toh
- Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion
- K. Miyata
- Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
- S. Uchida
- Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
- K. Nishina
- Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU)
- K. Osada
- Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
- K. Itaka
- Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
- N. Nishiyama
- Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology
- H. Mizusawa
- Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU)
- T. Yamasoba
- Department of Otorhinolaryngology and Head and Neck Surgery, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
- T. Yokota
- Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU)
- K. Kataoka
- Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion
- DOI
- https://doi.org/10.1038/s41467-017-00952-3
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 9
Abstract
There are only a few examples of nanocarriers that can transport bioactive substances across the blood-brain barrier. Here the authors show that by rapid glycaemic increase the accumulation of a glucosylated nanocarrier in the brain can be controlled.
