Nature Communications (Sep 2022)
PIM1 promotes hepatic conversion by suppressing reprogramming-induced ferroptosis and cell cycle arrest
- Yangyang Yuan,
- Chenwei Wang,
- Xuran Zhuang,
- Shaofeng Lin,
- Miaomiao Luo,
- Wankun Deng,
- Jiaqi Zhou,
- Lihui Liu,
- Lina Mao,
- Wenbo Peng,
- Jian Chen,
- Qiangsong Wang,
- Yilai Shu,
- Yu Xue,
- Pengyu Huang
Affiliations
- Yangyang Yuan
- Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College
- Chenwei Wang
- MOE Key Laboratory of Molecular Biophysics, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Center for Artificial Intelligence Biology, Institute of Artificial Intelligence, College of Life Science and Technology, Huazhong University of Science and Technology
- Xuran Zhuang
- School of Life Science and Technology, ShanghaiTech University
- Shaofeng Lin
- MOE Key Laboratory of Molecular Biophysics, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Center for Artificial Intelligence Biology, Institute of Artificial Intelligence, College of Life Science and Technology, Huazhong University of Science and Technology
- Miaomiao Luo
- Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College
- Wankun Deng
- MOE Key Laboratory of Molecular Biophysics, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Center for Artificial Intelligence Biology, Institute of Artificial Intelligence, College of Life Science and Technology, Huazhong University of Science and Technology
- Jiaqi Zhou
- MOE Key Laboratory of Molecular Biophysics, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Center for Artificial Intelligence Biology, Institute of Artificial Intelligence, College of Life Science and Technology, Huazhong University of Science and Technology
- Lihui Liu
- Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College
- Lina Mao
- Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College
- Wenbo Peng
- School of Life Science and Technology, ShanghaiTech University
- Jian Chen
- ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and Institutes of Biomedical Sciences, Fudan University
- Qiangsong Wang
- Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College
- Yilai Shu
- ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and Institutes of Biomedical Sciences, Fudan University
- Yu Xue
- MOE Key Laboratory of Molecular Biophysics, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Center for Artificial Intelligence Biology, Institute of Artificial Intelligence, College of Life Science and Technology, Huazhong University of Science and Technology
- Pengyu Huang
- Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College
- DOI
- https://doi.org/10.1038/s41467-022-32976-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Protein kinase-mediated phosphorylation plays a critical role in many biological processes. Here the authors develop a trans-omics-based algorithm called Central Kinase Inference to integrate quantitative transcriptomic and phosphoproteomic data, finding that PIM1 promotes hepatic conversion by suppressing reprogramming-induced ferroptosis and cell cycle arrest.
