Nature Communications (Apr 2023)
RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes
- Megha Subramanian,
- James McIninch,
- Ivan Zlatev,
- Mark K. Schlegel,
- Charalambos Kaittanis,
- Tuyen Nguyen,
- Saket Agarwal,
- Timothy Racie,
- Martha Arbaiza Alvarado,
- Kelly Wassarman,
- Thomas S. Collins,
- Tyler Chickering,
- Christopher R. Brown,
- Karyn Schmidt,
- Adam B. Castoreno,
- Svetlana Shulga-Morskaya,
- Elena Stamenova,
- Kira Buckowing,
- Daniel Berman,
- Joseph D. Barry,
- Anna Bisbe,
- Martin A. Maier,
- Kevin Fitzgerald,
- Vasant Jadhav
Affiliations
- Megha Subramanian
- Alnylam Pharmaceuticals
- James McIninch
- Alnylam Pharmaceuticals
- Ivan Zlatev
- Alnylam Pharmaceuticals
- Mark K. Schlegel
- Alnylam Pharmaceuticals
- Charalambos Kaittanis
- Alnylam Pharmaceuticals
- Tuyen Nguyen
- Alnylam Pharmaceuticals
- Saket Agarwal
- Alnylam Pharmaceuticals
- Timothy Racie
- Alnylam Pharmaceuticals
- Martha Arbaiza Alvarado
- Alnylam Pharmaceuticals
- Kelly Wassarman
- Alnylam Pharmaceuticals
- Thomas S. Collins
- Alnylam Pharmaceuticals
- Tyler Chickering
- Alnylam Pharmaceuticals
- Christopher R. Brown
- Alnylam Pharmaceuticals
- Karyn Schmidt
- Alnylam Pharmaceuticals
- Adam B. Castoreno
- Alnylam Pharmaceuticals
- Svetlana Shulga-Morskaya
- Alnylam Pharmaceuticals
- Elena Stamenova
- Alnylam Pharmaceuticals
- Kira Buckowing
- Alnylam Pharmaceuticals
- Daniel Berman
- Alnylam Pharmaceuticals
- Joseph D. Barry
- Alnylam Pharmaceuticals
- Anna Bisbe
- Alnylam Pharmaceuticals
- Martin A. Maier
- Alnylam Pharmaceuticals
- Kevin Fitzgerald
- Alnylam Pharmaceuticals
- Vasant Jadhav
- Alnylam Pharmaceuticals
- DOI
- https://doi.org/10.1038/s41467-023-37774-5
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 12
Abstract
Here the authors propose an RNA interference-based switch for dynamic control of AAV transgene expression. In this approach, transgene expression may be silenced by RNAi and subsequently recovered using REVERSIR oligonucleotides.
