Bleeding before prophylaxis in severe hemophilia: paradigm shift over two decades

• Annelies Nijdam,
• Carmen Altisent,
• Manuel D. Carcao,
• Ana R. Cid,
• Ségolène Claeyssens-Donadel,
• Karin Kurnik,
• Rolf Ljung,
• Beatrice Nolan,
• Pia Petrini,
• Helen Platokouki,
• Anne Rafowicz,
• Angela E. Thomas,
• Kathelijn Fischer

Affiliations

Annelies Nijdam

Van Creveldkliniek, Center for Benign Hematology, Thrombosis and Hemostasis, University Medical Center Utrecht, Netherlands

Carmen Altisent

Unitat Hemofilia Hospital Vall d’Hebron, Barcelona, Spain

Manuel D. Carcao

Division of Haematology/Oncology, Department of Paediatrics and Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada

Ana R. Cid

Unidad de Hemostasia y Trombosis, Hospital Universitario la Fe, Valencia, Spain

Ségolène Claeyssens-Donadel

CHU Purpan Centre de traitement des hémophiles, Toulouse, France

Karin Kurnik

Dr. von Haunersches Children’s Hospital, University of Munich, Germany

Rolf Ljung

Lund University, Department of Clinical Sciences Lund -Paediatrics and Malmö Haemostasis & Thrombosis Centre, Skåne University Hospital, Malmö, Sweden

Beatrice Nolan

Department of Haematology Oncology, Our Lady’s Children’s Hospital, Crumlin, Dublin, Ireland

Pia Petrini

Paediatric Department of Coagulation Disorders, Karolinska University Hospital, Stockholm, Sweden

Helen Platokouki

St. Sophia Children’s Hospital, Haemophilia-Haemostasis Unit, Athens, Greece

Anne Rafowicz

Centre Régional de Traitement de l’Hémophilie et Autres Maladies Hémorragiques, Centre Hospitalier Universitaire de Bicêtre, Paris, France

Angela E. Thomas

Department of Haematology, Royal Hospital for Sick Children, Edinburgh, Scotland

Kathelijn Fischer

Van Creveldkliniek, Center for Benign Hematology, Thrombosis and Hemostasis, University Medical Center Utrecht, Netherlands;Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands