Mechanism of pore opening in the calcium-activated chloride channel TMEM16A

Andy K. M. Lam; Raimund Dutzler

doi:10.1038/s41467-020-20788-8

Nature Communications (Feb 2021)

Mechanism of pore opening in the calcium-activated chloride channel TMEM16A

Andy K. M. Lam,
Raimund Dutzler

Affiliations

Andy K. M. Lam: Department of Biochemistry, University of Zurich
Raimund Dutzler: Department of Biochemistry, University of Zurich

DOI: https://doi.org/10.1038/s41467-020-20788-8
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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The anion channel TMEM16A is activated by intracellular Ca2+ in a highly cooperative process. Here authors combine electrophysiology and autocorrelation analysis to observe the sampling of intermediate conformations during gating.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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