Polymorphisms of MicroRNA-146a Gene in Behcet’s Disease in Iraqi Patients

Abstract

The present study was carried out to detect the association of miR-146a haplotypes polymorphisms with Behcet’s Disease in Iraqi patients, PCR-SSCP technique used in present study, blood was used to DNA extraction, the results show that there was strong association between miR-146a and Behçet’s Disease there were two patterns (A and B), polymorphisms show significant differences (p>0.05) between patients and control where haplotype A was appeared in control with (4% ) while in patients (43%) and haplotype B was appeared in control with (96% ) while in patients (57%). The present study concluded that there was association between miR-146a polymorphisms with Behçet’s Disease, our finding need more investigation to use this polymorphism as early indication of Behçet’s Disease incidence.

Keywords

• mir-146a
• pcr-sscp technique
• haplotypes
• polymorphisms