Four New 2-(2-Phenylethyl)chromone Derivatives from Chinese Agarwood Produced via the Whole-Tree Agarwood-Inducing Technique
Yang-Yang Liu,
De-Li Chen,
Jian-He Wei,
Jian Feng,
Zheng Zhang,
Yun Yang,
Wei Zheng
Affiliations
Yang-Yang Liu
Institute of Medicinal Plant Development (National Engineering Laboratory for Breeding of Endangered Medicinal Materials), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
De-Li Chen
Hainan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medicinal Sciences & Peking Union Medical College (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Haikou 570311, China
Jian-He Wei
Institute of Medicinal Plant Development (National Engineering Laboratory for Breeding of Endangered Medicinal Materials), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
Jian Feng
Hainan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medicinal Sciences & Peking Union Medical College (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Haikou 570311, China
Zheng Zhang
Institute of Medicinal Plant Development (National Engineering Laboratory for Breeding of Endangered Medicinal Materials), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
Yun Yang
Institute of Medicinal Plant Development (National Engineering Laboratory for Breeding of Endangered Medicinal Materials), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
Wei Zheng
Hainan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medicinal Sciences & Peking Union Medical College (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Haikou 570311, China
Four new 2-(2-phenylethyl)chromone derivatives (1–4) were isolated from the EtOH extract of Chinese agarwood produced via the whole-tree agarwood-inducing technique, coming from Aquilaria sinensis (Lour.) Spreng. (Thymelaeaceae). Their structures were elucidated by extensive spectroscopic methods, such as UV, IR, MS, 1D as well as 2D NMR. All of the isolates were then assessed for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7. Compound 1 exhibited significant inhibitory activity with an IC50 value of 4.6 μM.