Haematologica (Jun 2009)

Angiotensin-(1–7) stimulates hematopoietic progenitor cells in vitro and in vivo

  • Silvia Heringer-Walther,
  • Klaus Eckert,
  • Sarah-Mai Schumacher,
  • Lutz Uharek,
  • Annika Wulf-Goldenberg,
  • Florian Gembardt,
  • Iduna Fichtner,
  • Heinz-Peter Schultheiss,
  • Kathy Rodgers,
  • Thomas Walther

DOI
https://doi.org/10.3324/haematol.2008.000034
Journal volume & issue
Vol. 94, no. 6

Abstract

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Effects of angiotensin (Ang)-(1–7), an AngII metabolite, on bone marrow-derived hematopoietic cells were studied. We identified Ang-(1–7) to stimulate proliferation of human CD34+ and mononuclear cells in vitro. Under in vivo conditions, we monitored proliferation and differentiation of human cord blood mononuclear cells in NOD/SCID mice. Ang-(1–7) stimulated differentially human cells in bone marrow and accumulated them in the spleen. The number of HLA-I+ and CD34+ cells in the bone marrow was increased 42-fold and 600-fold, respectively. These results indicate a decisive impact of Ang-(1–7) on hematopoiesis and its promising therapeutic potential in diseases requiring progenitor stimulation.