The possibility of early detection of atherosclerotic vascular lesions in rheumatic diseases

Abstract

Identification of subclinical lesions of the heart and blood vessels in patients with rheumatic diseases (RD), as well as the comparison of subclinical markers of cardiovascular lesions in patients with RD and RD patients without having one of the risk factors for cardiovascular disease. Surveyed 56 patients (15 men and 41 female) at the age of 45.2 ± 13.42 years with different rheumatic diseases. For the comparison group surveyed residents of one of the districts of Saint Petersburg (50 people). All patients have been conducted questioning, characterizes lifestyle, risk factors, comorbidity and drug therapy. Anthropometry were measured in weight, height with a calculation of body mass index, waist circumference, hip circumference. Endothelial dysfunction study conducted on the Endo Pat 2000 (company “Itamar Medical Ltd, Israel): reactive hyperemia index (RHI) and augmentation index (AI). Dysfunction of the endothelium have registered a value of RHI 9.6 m/s compared to the 2nd and 3rd groups of patients with RD. We have identified correlate titer of antinuclear factor, reactive hyperemia index (RHI), augmentation index (AI, EndoPat), the central pulse pressure (PP) show integration structures of the cardiovascular system in the pathological process in RD, including asymptomatic from the system.

Keywords

• rheumatic disease
• endothelial dysfunction
• thickness intima-media
• atherosclerosis