Neurotoxicities associated with checkpoint inhibitors: Two case reports and a review of the literature

Abstract

Abstract We report a case of nivolumab‐induced delayed‐onset aseptic meningitis and a case of limbic encephalitis and peripheral nerve palsy with toxicity relapse 6 months after initial presentation. The atypical presentations contribute to our knowledge of these rare events and reinforce the necessity for vigilant monitoring and a multidisciplinary treatment approach.

Keywords

• aseptic meningitis
• checkpoint inhibitor
• encephalitis
• ipilimumab
• neurotoxicity
• nivolumab