Nature Communications (Feb 2018)

How ligand binds to the type 1 insulin-like growth factor receptor

  • Yibin Xu,
  • Geoffrey K.-W. Kong,
  • John G. Menting,
  • Mai B. Margetts,
  • Carlie A. Delaine,
  • Lauren M. Jenkin,
  • Vladislav V. Kiselyov,
  • Pierre De Meyts,
  • Briony E. Forbes,
  • Michael C. Lawrence

DOI
https://doi.org/10.1038/s41467-018-03219-7
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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The human type 1 insulin-like growth factor receptor (IGF-1R) is important for normal human growth and development. Here, the authors present the crystal structures of the IGF-1R ectodomain both in its apo form and in complex with its ligand insulin-like growth factor I and discuss the receptor activation mechanism.