Polymorphisms in the NADPH quinone dehydrogenase 1 (NQ01) gene in Saudi patients with acute myeloid leukemia

Abstract

Acute myeloid leukemia (AML) is a hematological malignancy that contains hereditary subgroups. AML can arise as a result of a previous myeloid malignancy. AML's molecular pathogenesis is not yet complete. NADPH quinone dehydrogenase 1 (NQ01), which is linked to AML, is one of a few handfuls of genes that have a role in AML pathogenesis. The goal of this study was to look at the roles of C609T and C465T polymorphisms in the NQ01 gene in the development of AML in Saudis. In this experimental study, 100 AML patients and 100 healthy controls were chosen. For the C609T and C465T PCR products, restriction enzymes were utilized in this study. AML cases and controls were investigated for genotype and allele frequencies. The average age of AML patients and control subjects was 39.9 ± 12.06 years. AML patients were 61% male and 39% female, while controls were 54% male and 46% female. The C609T and C465T polymorphisms in the NQ01 gene were not linked with any of the genotypes (p > 0.05). According to the findings of this investigation, the C609T and C465T polymorphisms play no effect in AML patients in Saudi Arabia.

Keywords

• AML
• NQ01
• C609T
• C465T and polymorphism