KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease

Julia Neitzel; Nicolai Franzmeier; Anna Rubinski; Martin Dichgans; Matthias Brendel; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Rainer Malik; Michael Ewers

doi:10.1038/s41467-021-23755-z

Nature Communications (Jun 2021)

KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease

Julia Neitzel,
Nicolai Franzmeier,
Anna Rubinski,
Martin Dichgans,
Matthias Brendel,
Alzheimer’s Disease Neuroimaging Initiative (ADNI),
Rainer Malik,
Michael Ewers

Affiliations

Julia Neitzel: Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU
Nicolai Franzmeier: Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU
Anna Rubinski: Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU
Martin Dichgans: Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU
Matthias Brendel: Department of Nuclear Medicine, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU
Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Rainer Malik: Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU
Michael Ewers: Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU

DOI: https://doi.org/10.1038/s41467-021-23755-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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The KL-VS haplotype of the Klotho gene has been associated with reduced risk of Alzheimer’s disease and dementia. Here the authors show an association between the KL-VS haplotype and amyloid-dependent tau accumulation using PET data.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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