Nature Communications (Aug 2022)

Deconvoluting complex correlates of COVID-19 severity with a multi-omic pandemic tracking strategy

  • Victoria N. Parikh,
  • Alexander G. Ioannidis,
  • David Jimenez-Morales,
  • John E. Gorzynski,
  • Hannah N. De Jong,
  • Xiran Liu,
  • Jonasel Roque,
  • Victoria P. Cepeda-Espinoza,
  • Kazutoyo Osoegawa,
  • Chris Hughes,
  • Shirley C. Sutton,
  • Nathan Youlton,
  • Ruchi Joshi,
  • David Amar,
  • Yosuke Tanigawa,
  • Douglas Russo,
  • Justin Wong,
  • Jessie T. Lauzon,
  • Jacob Edelson,
  • Daniel Mas Montserrat,
  • Yongchan Kwon,
  • Simone Rubinacci,
  • Olivier Delaneau,
  • Lorenzo Cappello,
  • Jaehee Kim,
  • Massa J. Shoura,
  • Archana N. Raja,
  • Nathaniel Watson,
  • Nathan Hammond,
  • Elizabeth Spiteri,
  • Kalyan C. Mallempati,
  • Gonzalo Montero-Martín,
  • Jeffrey Christle,
  • Jennifer Kim,
  • Anna Kirillova,
  • Kinya Seo,
  • Yong Huang,
  • Chunli Zhao,
  • Sonia Moreno-Grau,
  • Steven G. Hershman,
  • Karen P. Dalton,
  • Jimmy Zhen,
  • Jack Kamm,
  • Karan D. Bhatt,
  • Alina Isakova,
  • Maurizio Morri,
  • Thanmayi Ranganath,
  • Catherine A. Blish,
  • Angela J. Rogers,
  • Kari Nadeau,
  • Samuel Yang,
  • Andra Blomkalns,
  • Ruth O’Hara,
  • Norma F. Neff,
  • Christopher DeBoever,
  • Sándor Szalma,
  • Matthew T. Wheeler,
  • Christian M. Gates,
  • Kyle Farh,
  • Gary P. Schroth,
  • Phil Febbo,
  • Francis deSouza,
  • Omar E. Cornejo,
  • Marcelo Fernandez-Vina,
  • Amy Kistler,
  • Julia A. Palacios,
  • Benjamin A. Pinsky,
  • Carlos D. Bustamante,
  • Manuel A. Rivas,
  • Euan A. Ashley

DOI
https://doi.org/10.1038/s41467-022-32397-8
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 10

Abstract

Read online

There is a genetic component to the risk of severe COVID-19, but the genetic effects are difficult to separate from social constructs that covary with genetic ancestry. To address this, the authors identify determinants of COVID-19 severity using admixture mapping, viral phylodynamics, and host immune and metagenomic sequencing.