Washing effect on superparamagnetic iron oxide nanoparticles
Laura-Karina Mireles,
Edward Sacher,
L’Hocine Yahia,
Sophie Laurent,
Dimitri Stanicki
Affiliations
Laura-Karina Mireles
Laboratoire d’Innovation et d’Analyse de Bioperformance, École Polytechnique de Montréal, C.P. 6079, Succursale Centre-ville, Montréal, Québec, Canada H3C 3A7; Corresponding author.
Edward Sacher
Laboratoire d’Innovation et d’Analyse de Bioperformance, École Polytechnique de Montréal, C.P. 6079, Succursale Centre-ville, Montréal, Québec, Canada H3C 3A7; Département de Génie physique, École Polytechnique de Montréal, C.P. 6079, Succursale Centre-ville, Montréal, Québec, Canada H3C 3A7
L’Hocine Yahia
Laboratoire d’Innovation et d’Analyse de Bioperformance, École Polytechnique de Montréal, C.P. 6079, Succursale Centre-ville, Montréal, Québec, Canada H3C 3A7
Sophie Laurent
Department of General, Organic, Biomedical Chemistry, NMR and Molecular Imaging Laboratory, Université de Mons, 19 Avenue Maistriau, B-7000 Mons, Belgium; Center for Microscopy and Molecular Imaging (CMMI), B-6041 Gosselies, Belgium
Dimitri Stanicki
Center for Microscopy and Molecular Imaging (CMMI), B-6041 Gosselies, Belgium
Much recent research on nanoparticles has occurred in the biomedical area, particularly in the area of superparamagnetic iron oxide nanoparticles (SPIONs); one such area of research is in their use as magnetically directed prodrugs. It has been reported that nanoscale materials exhibit properties different from those of materials in bulk or on a macro scale [1]. Further, an understanding of the batch-to-batch reproducibility and uniformity of the SPION surface is essential to ensure safe biological applications, as noted in the accompanying article [2], because the surface is the first layer that affects the biological response of the human body. Here, we consider a comparison of the surface chemistries of a batch of SPIONs, before and after the supposedly gentle process of dialysis in water. Keywords: Superparamagnetic iron oxide nanoparticles, Washing effect, Surface chemistry, Prodrugs, Dialysis effect
