Comparing Mean Platelet Volume Values in Patients with Recurrent Aphthous Stomatitis and Patients with Behcet’s Disease

Abstract

Objective:Platelets play an important role in the pathogenesis of disorders associated with the local or systemic inflammation. Mean platelet volume (MPV) is a marker for platelet activation, and larger platelets are more activated. In this study, we aimed to investigate MPV values in patients with Behcet’s disease, patients with recurrent aphthous stomatitis, and controls.Methods:Patients with Behcet’s disease and patients with recurrent aphthous stomatitis who presented to a dermatology outpatients clinic were enrolled in this study. Age, sex, MPV values, vitamin B12, and TSH were retrospectively recorded.Results:A total of 113 patients with recurrent aphthous stomatitis, 87 patients with Behcet’s disease, and 71 healthy controls were enrolled in this study. Among them, 74 (65.5%) of the patients with recurrent aphthous stomatitis were females, and 39 (35.5%) were males. Additionally, 50 (63.4%) of the patients with Behcet’s disease were females, and 37 (42.5%) were males. Finally, 45 (63.4%) of the controls were females, and 26 (36.6%) were males. There was no statistically significant difference in MPV values in patients with Behcet’s disease, patients with recurrent aphthous stomatitis, and control group.Conclusion:MPV is a simple and useful parameter seen in routine complete blood count (CBC) laboratory tests. It is investigated as an inflammation marker. Although in some studies, MPV was high in patients with Behcet’s disease, in our study, we did not observe any statistically significant difference in patients with Behcet’s disease, patients with recurrent aphthous stomatitis, and control group.

Keywords

• MPV
• recurrent aphthous stomatitis
• Behcet’s disease