Nature Communications (Jan 2021)
Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction
- Lukas S. Tombor,
- David John,
- Simone F. Glaser,
- Guillermo Luxán,
- Elvira Forte,
- Milena Furtado,
- Nadia Rosenthal,
- Nina Baumgarten,
- Marcel H. Schulz,
- Janina Wittig,
- Eva-Maria Rogg,
- Yosif Manavski,
- Ariane Fischer,
- Marion Muhly-Reinholz,
- Kathrin Klee,
- Mario Looso,
- Carmen Selignow,
- Till Acker,
- Sofia-Iris Bibli,
- Ingrid Fleming,
- Ralph Patrick,
- Richard P. Harvey,
- Wesley T. Abplanalp,
- Stefanie Dimmeler
Affiliations
- Lukas S. Tombor
- Institute for Cardiovascular Regeneration, Goethe University Frankfurt
- David John
- Institute for Cardiovascular Regeneration, Goethe University Frankfurt
- Simone F. Glaser
- Institute for Cardiovascular Regeneration, Goethe University Frankfurt
- Guillermo Luxán
- Institute for Cardiovascular Regeneration, Goethe University Frankfurt
- Elvira Forte
- The Jackson Laboratory
- Milena Furtado
- The Jackson Laboratory
- Nadia Rosenthal
- The Jackson Laboratory
- Nina Baumgarten
- Institute for Cardiovascular Regeneration, Goethe University Frankfurt
- Marcel H. Schulz
- Institute for Cardiovascular Regeneration, Goethe University Frankfurt
- Janina Wittig
- Institute for Vascular Signaling, Goethe University Frankfurt
- Eva-Maria Rogg
- Institute for Cardiovascular Regeneration, Goethe University Frankfurt
- Yosif Manavski
- Institute for Cardiovascular Regeneration, Goethe University Frankfurt
- Ariane Fischer
- Institute for Cardiovascular Regeneration, Goethe University Frankfurt
- Marion Muhly-Reinholz
- Institute for Cardiovascular Regeneration, Goethe University Frankfurt
- Kathrin Klee
- German Center of Cardiovascular Research (DZHK)
- Mario Looso
- Cardiopulmonary Institute
- Carmen Selignow
- Department of Pathology, University Giessen
- Till Acker
- Cardiopulmonary Institute
- Sofia-Iris Bibli
- Institute for Vascular Signaling, Goethe University Frankfurt
- Ingrid Fleming
- Cardiopulmonary Institute
- Ralph Patrick
- Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute
- Richard P. Harvey
- Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute
- Wesley T. Abplanalp
- Institute for Cardiovascular Regeneration, Goethe University Frankfurt
- Stefanie Dimmeler
- Institute for Cardiovascular Regeneration, Goethe University Frankfurt
- DOI
- https://doi.org/10.1038/s41467-021-20905-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Endothelial cells play a critical role in the adaptation of tissues to injury and show a remarkable plasticity. Here the authors show, using single cell sequencing, that endothelial cells acquire a transient mesenchymal state associated with metabolic adaptation after myocardial infarction.
