Nature Communications (Jan 2021)

Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction

  • Lukas S. Tombor,
  • David John,
  • Simone F. Glaser,
  • Guillermo Luxán,
  • Elvira Forte,
  • Milena Furtado,
  • Nadia Rosenthal,
  • Nina Baumgarten,
  • Marcel H. Schulz,
  • Janina Wittig,
  • Eva-Maria Rogg,
  • Yosif Manavski,
  • Ariane Fischer,
  • Marion Muhly-Reinholz,
  • Kathrin Klee,
  • Mario Looso,
  • Carmen Selignow,
  • Till Acker,
  • Sofia-Iris Bibli,
  • Ingrid Fleming,
  • Ralph Patrick,
  • Richard P. Harvey,
  • Wesley T. Abplanalp,
  • Stefanie Dimmeler

DOI
https://doi.org/10.1038/s41467-021-20905-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

Read online

Endothelial cells play a critical role in the adaptation of tissues to injury and show a remarkable plasticity. Here the authors show, using single cell sequencing, that endothelial cells acquire a transient mesenchymal state associated with metabolic adaptation after myocardial infarction.