Nature Communications (Sep 2019)
Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development
- Shaohai Fang,
- Jia Li,
- Yang Xiao,
- Minjung Lee,
- Lei Guo,
- Wei Han,
- Tingting Li,
- Matthew C. Hill,
- Tingting Hong,
- William Mo,
- Rang Xu,
- Ping Zhang,
- Fen Wang,
- Jiang Chang,
- Yubin Zhou,
- Deqiang Sun,
- James F. Martin,
- Yun Huang
Affiliations
- Shaohai Fang
- Center for Epigenetics & Disease Prevention, Institute of Biosciences and Technology, Texas A&M University
- Jia Li
- Center for Epigenetics & Disease Prevention, Institute of Biosciences and Technology, Texas A&M University
- Yang Xiao
- Texas Heart Institute, Cardiomyocyte Renewal Lab
- Minjung Lee
- Center for Epigenetics & Disease Prevention, Institute of Biosciences and Technology, Texas A&M University
- Lei Guo
- Center for Epigenetics & Disease Prevention, Institute of Biosciences and Technology, Texas A&M University
- Wei Han
- Center for Epigenetics & Disease Prevention, Institute of Biosciences and Technology, Texas A&M University
- Tingting Li
- Center for Epigenetics & Disease Prevention, Institute of Biosciences and Technology, Texas A&M University
- Matthew C. Hill
- Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza
- Tingting Hong
- Center for Epigenetics & Disease Prevention, Institute of Biosciences and Technology, Texas A&M University
- William Mo
- Center for Epigenetics & Disease Prevention, Institute of Biosciences and Technology, Texas A&M University
- Rang Xu
- Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University
- Ping Zhang
- Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University
- Fen Wang
- Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University
- Jiang Chang
- Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University
- Yubin Zhou
- Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University
- Deqiang Sun
- Center for Epigenetics & Disease Prevention, Institute of Biosciences and Technology, Texas A&M University
- James F. Martin
- Texas Heart Institute, Cardiomyocyte Renewal Lab
- Yun Huang
- Center for Epigenetics & Disease Prevention, Institute of Biosciences and Technology, Texas A&M University
- DOI
- https://doi.org/10.1038/s41467-019-12325-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 18
Abstract
Tet-mediated DNA demethylation is intimately involved in reguatling embryonic development. Here the authors characterise DNA methylation and hydroxymethylation dynamics during early cardiac development in both human and mice and provide evidence that Tet-mediated DNA demethylation plays a role in regulating chromatin organization during early heart development.
