Nature Communications (May 2020)

Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles

  • Luke D. Halder,
  • Emeraldo A. H. Jo,
  • Mohammad Z. Hasan,
  • Marta Ferreira-Gomes,
  • Thomas Krüger,
  • Martin Westermann,
  • Diana I. Palme,
  • Günter Rambach,
  • Niklas Beyersdorf,
  • Cornelia Speth,
  • Ilse D. Jacobsen,
  • Olaf Kniemeyer,
  • Berit Jungnickel,
  • Peter F. Zipfel,
  • Christine Skerka

DOI
https://doi.org/10.1038/s41467-020-16241-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 19

Abstract

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Extracellular vesicles can carry immunoregulatory cytokines such as TGF-β. Here the authors use CD11b-deficient mice and macrophages to show that such vesicles carrying TGF-β are produced in response to Candida albicans infections and can limit the proinflammatory response partly via a positive feedback on TGF-β production by endothelial cells.