Nature Communications (Dec 2019)
Global redox proteome and phosphoproteome analysis reveals redox switch in Akt
- Zhiduan Su,
- James G. Burchfield,
- Pengyi Yang,
- Sean J. Humphrey,
- Guang Yang,
- Deanne Francis,
- Sabina Yasmin,
- Sung-Young Shin,
- Dougall M. Norris,
- Alison L. Kearney,
- Miro A. Astore,
- Jonathan Scavuzzo,
- Kelsey H. Fisher-Wellman,
- Qiao-Ping Wang,
- Benjamin L. Parker,
- G. Gregory Neely,
- Fatemeh Vafaee,
- Joyce Chiu,
- Reichelle Yeo,
- Philip J. Hogg,
- Daniel J. Fazakerley,
- Lan K. Nguyen,
- Serdar Kuyucak,
- David E. James
Affiliations
- Zhiduan Su
- Charles Perkins Centre, The University of Sydney
- James G. Burchfield
- Charles Perkins Centre, The University of Sydney
- Pengyi Yang
- Charles Perkins Centre, The University of Sydney
- Sean J. Humphrey
- Charles Perkins Centre, The University of Sydney
- Guang Yang
- Charles Perkins Centre, The University of Sydney
- Deanne Francis
- Charles Perkins Centre, The University of Sydney
- Sabina Yasmin
- School of Physics, The University of Sydney
- Sung-Young Shin
- Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University
- Dougall M. Norris
- Charles Perkins Centre, The University of Sydney
- Alison L. Kearney
- Charles Perkins Centre, The University of Sydney
- Miro A. Astore
- School of Physics, The University of Sydney
- Jonathan Scavuzzo
- Charles Perkins Centre, The University of Sydney
- Kelsey H. Fisher-Wellman
- Brody School of Medicine, Physiology Department, East Carolina University
- Qiao-Ping Wang
- Charles Perkins Centre, The University of Sydney
- Benjamin L. Parker
- Charles Perkins Centre, The University of Sydney
- G. Gregory Neely
- Charles Perkins Centre, The University of Sydney
- Fatemeh Vafaee
- Charles Perkins Centre, The University of Sydney
- Joyce Chiu
- The Centenary Institute
- Reichelle Yeo
- The Centenary Institute
- Philip J. Hogg
- The Centenary Institute
- Daniel J. Fazakerley
- Charles Perkins Centre, The University of Sydney
- Lan K. Nguyen
- Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University
- Serdar Kuyucak
- School of Physics, The University of Sydney
- David E. James
- Charles Perkins Centre, The University of Sydney
- DOI
- https://doi.org/10.1038/s41467-019-13114-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 18
Abstract
Crosstalk between protein oxidation and other post-translational modifications remains unexplored. Here, the authors map the phosphoproteome, cysteine redox proteome and total proteome of adipocytes under acute oxidative stress and reveal crosstalk between cysteine oxidation and phosphorylation-based signalling.
