A spontaneous ovarian teratoma in an FVB/n female mouse: Case report and literature review

Paula Alexandra Martins de-Oliveira; Ana I. Faustino-Rocha; Rui M. Gil da-Costa; Elisabete Nascimento Goncalves; Ana Margarida Calado; Catarina Jota Baptista; Adelina Gama; Fernanda Seixas

doi:10.5455/OVJ.2023.v13.i9.19

Open Veterinary Journal (Sep 2023)

A spontaneous ovarian teratoma in an FVB/n female mouse: Case report and literature review

Paula Alexandra Martins de-Oliveira,
Ana I. Faustino-Rocha,
Rui M. Gil da-Costa,
Elisabete Nascimento Goncalves,
Ana Margarida Calado,
Catarina Jota Baptista,
Adelina Gama,
Fernanda Seixas

Affiliations

Paula Alexandra Martins de-Oliveira: 1 Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Inov4Agro, University of Tras-os-Montes and Alto Douro (UTAD), 5000-801, Vila Real, Portugal 2 Institute for Innovation, Capacity Building and Sustainability of Agri-food Production (Inov4Agro), 5000-801, Vila Real, Portugal 3 Department of Veterinary Sciences, UTAD, 5000-801, Vila Real, Portugal
Ana I. Faustino-Rocha: 1 Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Inov4Agro, University of Tras-os-Montes and Alto Douro (UTAD), 5000-801, Vila Real, Portugal 2 Institute for Innovation, Capacity Building and Sustainability of Agri-food Production (Inov4Agro), 5000-801, Vila Real, Portugal4 Department of Zootechnics, School of Sciences and Technology, University of Évora, 7004-516 Évora, Portugal 5 Comprehensive Health Research Center, 7004-516 Évora, Portugal
Rui M. Gil da-Costa: 1 Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Inov4Agro, University of Tras-os-Montes and Alto Douro (UTAD), 5000-801, Vila Real, Portugal 2 Institute for Innovation, Capacity Building and Sustainability of Agri-food Production (Inov4Agro), 5000-801, Vila Real, Portugal6 Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center (Porto.CCC), 4200-072 Porto, Portugal 7Biomedicine Research Center (CEBIMED), Faculty of Health Sciences, Fernando Pessoa University, 4249-004 Porto, Portugal 8Research Department, LPCC-Portuguese League Against Cancer (NRNorte), 4200-172 Porto, Portugal 9 Post-graduate Programme in Adult Health (PPGSAD), Morphology Department and University Hospital (HUUFMA), Federal University of Maranhao (UFMA), Sao Luís 65080-805, Brazil 10Associate Laboratory for Animal and Veterinary Science (AL4AnimalS), Animal and Veterinary Research Centre (CECAV), UTAD, 5000-801 Vila Real, Portugal
Elisabete Nascimento Goncalves: 1 Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Inov4Agro, University of Tras-os-Montes and Alto Douro (UTAD), 5000-801, Vila Real, Portugal 2 Institute for Innovation, Capacity Building and Sustainability of Agri-food Production (Inov4Agro), 5000-801, Vila Real, Portugal
Ana Margarida Calado: 3 Department of Veterinary Sciences, UTAD, 5000-801, Vila Real, Portugal
Catarina Jota Baptista: 10Associate Laboratory for Animal and Veterinary Science (AL4AnimalS), Animal and Veterinary Research Centre (CECAV), UTAD, 5000-801 Vila Real, Portugal
Adelina Gama: 1 Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Inov4Agro, University of Tras-os-Montes and Alto Douro (UTAD), 5000-801, Vila Real, Portugal 2 Institute for Innovation, Capacity Building and Sustainability of Agri-food Production (Inov4Agro), 5000-801, Vila Real, Portugal 3 Department of Veterinary Sciences, UTAD, 5000-801, Vila Real, Portugal11IBIOMED – Instituto de Biomedicina, Universidad de León, León, Spain. 12Faculty of Veterinary of Medicine, Lusófona University of Humanities and Technology, Lisbon, Portugal.
Fernanda Seixas: 3 Department of Veterinary Sciences, UTAD, 5000-801, Vila Real, Portugal

DOI: https://doi.org/10.5455/OVJ.2023.v13.i9.19
Journal volume & issue: Vol. 13, no. 9
pp. 1223 – 1227

Abstract

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Background: Teratomas are rare types of germ cell neoplasms composed of various differentiated or undifferentiated tissues. Case Description: A 25-week-old female control FVB/n mouse in a 4-week toxicity study presented abdominal distension and poor body condition. It was euthanized, and the necropsy exam revealed a large mass connected to the tip of the right uterine horn, occupying the entire abdominal cavity. Microscopically, this mass showed areas of epidermal differentiation, with laminated keratin and sebaceous glands, differentiation into respiratory and digestive epithelium, cartilage, bone, and extensive areas of differentiation into the nervous tissue, being classified as an ovarian teratoma. Conclusion: As far as authors know, the occurrence of ovarian teratomas in FVB/n mouse strain has never been previously described. [Open Vet J 2023; 13(9.000): 1223-1227]

Published in Open Veterinary Journal

ISSN: 2226-4485 (Print); 2218-6050 (Online)
Publisher: Tripoli University
Country of publisher: Libya
LCC subjects: Science: Zoology
Website: http://www.openveterinaryjournal.com

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