A hydrogen sulphide-responsive and depleting nanoplatform for cancer photodynamic therapy

Yuqi Zhang; Jing Fang; Shuyue Ye; Yan Zhao; Anna Wang; Qiulian Mao; Chaoxiang Cui; Yali Feng; Jiachen Li; Sunao Li; Mingyang Zhang; Haibin Shi

doi:10.1038/s41467-022-29284-7

Nature Communications (Mar 2022)

A hydrogen sulphide-responsive and depleting nanoplatform for cancer photodynamic therapy

Yuqi Zhang,
Jing Fang,
Shuyue Ye,
Yan Zhao,
Anna Wang,
Qiulian Mao,
Chaoxiang Cui,
Yali Feng,
Jiachen Li,
Sunao Li,
Mingyang Zhang,
Haibin Shi

Affiliations

Yuqi Zhang: State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University
Jing Fang: State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University
Shuyue Ye: State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University
Yan Zhao: State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University
Anna Wang: State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University
Qiulian Mao: State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University
Chaoxiang Cui: State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University
Yali Feng: State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University
Jiachen Li: State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University
Sunao Li: Department of Forensic Sciences, School of Basic Medicine and Biological Sciences, Soochow University
Mingyang Zhang: Department of Forensic Sciences, School of Basic Medicine and Biological Sciences, Soochow University
Haibin Shi: State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University

DOI: https://doi.org/10.1038/s41467-022-29284-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Abnormal levels of intracellular hydrogen sulphide (H2S) have been associated with different pathological conditions, including cancer. Here the authors report the design of a H2S-responsive and -depleting nanoplatform that, combined with NIR-II photodynamic properties, can be used for H2S imaging and cancer therapy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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