Nature Communications (Mar 2021)

Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms

  • Gergo Gogl,
  • Kristina V. Tugaeva,
  • Pascal Eberling,
  • Camille Kostmann,
  • Gilles Trave,
  • Nikolai N. Sluchanko

DOI
https://doi.org/10.1038/s41467-021-21908-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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14-3-3 proteins recognize phosphorylated motifs within numerous protein partners. Here, the authors characterize the binding of all human 14-3-3 isoforms to four E6 oncoproteins, and identify a fixed order of 14-3-3 binding affinities that is conserved in 14-3-3:phosphoprotein interactions across the proteome.