Pharmacological effects of combined antitubercular preparation "Protub-3®" at single introduction in experimental conditions

Abstract

An experimental preclinical study of combined antitubercular preparation "Protub-3®" was conducted. Under conditions of performed research "Protub-3®" in dose 8 mg/kg didn't cause pharmacological effect in all registered indices in experiment. But it was established that the preparation in doses more than 8 mg/kg caused a number of dose-dependent pharmacological effects. Increase of rectal temperature, systolic arterial pressure, sum-liminal index, consumption of oxygen and simultaneous decrease of carbonic gas emission, decrease of duration of hexenal sleep, decrease of heart rate, suppression of spontaneous motive activity, rats' research reflex can be related to the number of estimation effects of "Protub-3®".

Keywords

• antitubercular preparation
• combined preparation
• isoniazid
• rifampicin
• piraziamid
• synthetic antibacterial means
• ansamicines
• collateral reactions
• pharmacological effect