Nature Communications (Sep 2021)

Pathway of Hsp70 interactions at the ribosome

  • Kanghyun Lee,
  • Thomas Ziegelhoffer,
  • Wojciech Delewski,
  • Scott E. Berger,
  • Grzegorz Sabat,
  • Elizabeth A. Craig

DOI
https://doi.org/10.1038/s41467-021-25930-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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Here, the authors use in vivo site-specific crosslinking to provide molecular-level insight into how the fungal Hsp70 chaperone system — the Ssb:Ssz1:Zuo1 triad — assists the folding process for the nascent peptide chain emerging from the ribosome tunnel.