Application and Prospect of RNA Profiling Analysis in Forensic Body Fluid Identification

Abstract

In forensic physical evidence identification, the accurate identification of the individual origin and their body fluid composition of the biological samples obtained from the crime scene play a critical role in determining the nature of a crime. In recent years, RNA profiling has become one of the fastest developing methods for body fluids identification. Due to the characteristics of tissue or body fluid specific expression, various types of RNA markers have been proven to be promising candidate markers for body fluids identification in previous studies. This review summarizes the research progress of RNA markers in body fluids identification, including the RNA markers that have been effectively verified in current research and their advantages and disadvantages. Meanwhile, this review prospects the application of RNA markers in forensic medicine.

Keywords

• forensic genetics
• body fluid
• ribonucleic acid （rna）
• capillary electrophoresis
• real-time quantitative polymerase chain reaction （rt-qpcr）
• high-throughput sequencing
• review