Application of biogenic surfactants for stabilization on alkaloid-free fraction isolated from Galega officinalis extract

Abstract

The article contains data on the influence of biogenic surfactants synthesized by bacteria Pseudomonas sp. PS-17 on the stability of emulsions based on alkaloid-free fraction isolated from Galega officinalis L. extract. The opti­mum concentrations of biogenic surfactants to stabilize investigated emulsionswere experimentally chosen. The chemical composition of alkaloid-free fractions from Galega officinalis L. extract before and after stabilization were investigated. The resulting substance is easier to administer to animals through a tube, which not only improves the accuracy of the dosage, but also increases its bioavailability. Reduction of glycosylated hemoglobin at 13.4 % and glucose content to the physiological values in the rats blood with experimental diabetes mellitus by administration within 14 days stabilized emulsions compared with the original emulsion shows that emulsion stabilized by the biogenic surfactant based on alkaloid-free fraction isolated from Galega officinalis an extract provides effective hyperglycemia compensation in rats under experimental diabetes mellitus, compared with the original mixture, which may be caused by changes in the proportion of biologically active substances in the extract while stabilizing and its better bioavailability.

Keywords

• biogenic surfactants
• Pseudomonas sp. PS-17
• emulsions
• alkaloid-free fraction of Galega officinalis L. extract
• experimental diabetes mellitus