Cryo-EM structure of type 1 IP3R channel in a lipid bilayer

Mariah R. Baker; Guizhen Fan; Alexander B. Seryshev; Melina A. Agosto; Matthew L. Baker; Irina I. Serysheva

doi:10.1038/s42003-021-02156-4

Communications Biology (May 2021)

Cryo-EM structure of type 1 IP3R channel in a lipid bilayer

Mariah R. Baker,
Guizhen Fan,
Alexander B. Seryshev,
Melina A. Agosto,
Matthew L. Baker,
Irina I. Serysheva

Affiliations

Mariah R. Baker: Department of Biochemistry and Molecular Biology, Structural Biology Imaging Center, McGovern Medical School at The University of Texas Health Science Center at Houston
Guizhen Fan: Department of Biochemistry and Molecular Biology, Structural Biology Imaging Center, McGovern Medical School at The University of Texas Health Science Center at Houston
Alexander B. Seryshev: Department of Biochemistry and Molecular Biology, Structural Biology Imaging Center, McGovern Medical School at The University of Texas Health Science Center at Houston
Melina A. Agosto: Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine
Matthew L. Baker: Department of Biochemistry and Molecular Biology, Structural Biology Imaging Center, McGovern Medical School at The University of Texas Health Science Center at Houston
Irina I. Serysheva: Department of Biochemistry and Molecular Biology, Structural Biology Imaging Center, McGovern Medical School at The University of Texas Health Science Center at Houston

DOI: https://doi.org/10.1038/s42003-021-02156-4
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 11

Abstract

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3D structure of full-length rat type 1 inositol 1,4,5-trisphosphate receptor reconstituted in lipid nanodisc is determined using single-particle cryo-electron microscopy. The study suggests conserved locations of protein-bound lipids among structurally diverse, homo-tetrameric ion channels.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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