Nature Communications (Mar 2023)
Tyrosyl-tRNA synthetase has a noncanonical function in actin bundling
- Biljana Ermanoska,
- Bob Asselbergh,
- Laura Morant,
- Maria-Luise Petrovic-Erfurth,
- Seyyedmohsen Hosseinibarkooie,
- Ricardo Leitão-Gonçalves,
- Leonardo Almeida-Souza,
- Sven Bervoets,
- Litao Sun,
- LaTasha Lee,
- Derek Atkinson,
- Akram Khanghahi,
- Ivaylo Tournev,
- Patrick Callaerts,
- Patrik Verstreken,
- Xiang-Lei Yang,
- Brunhilde Wirth,
- Avital A. Rodal,
- Vincent Timmerman,
- Bruce L. Goode,
- Tanja A. Godenschwege,
- Albena Jordanova
Affiliations
- Biljana Ermanoska
- Center for Molecular Neurology, VIB, University of Antwerp
- Bob Asselbergh
- Neuromics Support Facility, VIB Center for Molecular Neurology, VIB
- Laura Morant
- Center for Molecular Neurology, VIB, University of Antwerp
- Maria-Luise Petrovic-Erfurth
- Center for Molecular Neurology, VIB, University of Antwerp
- Seyyedmohsen Hosseinibarkooie
- Institute of Human Genetics; Center for Molecular Medicine Cologne; Center for Rare Diseases Cologne, University Hospital of Cologne; University of Cologne
- Ricardo Leitão-Gonçalves
- Center for Molecular Neurology, VIB, University of Antwerp
- Leonardo Almeida-Souza
- Center for Molecular Neurology, VIB, University of Antwerp
- Sven Bervoets
- Center for Molecular Neurology, VIB, University of Antwerp
- Litao Sun
- Department of Molecular Medicine, The Scripps Research Institute
- LaTasha Lee
- Department of Biological Sciences, Florida Atlantic University
- Derek Atkinson
- Center for Molecular Neurology, VIB, University of Antwerp
- Akram Khanghahi
- Center for Molecular Neurology, VIB, University of Antwerp
- Ivaylo Tournev
- Department of Neurology, Medical University-Sofia
- Patrick Callaerts
- Department of Human Genetics, KU Leuven
- Patrik Verstreken
- VIB-KU Leuven Center for Brain & Disease Research
- Xiang-Lei Yang
- Department of Molecular Medicine, The Scripps Research Institute
- Brunhilde Wirth
- Institute of Human Genetics; Center for Molecular Medicine Cologne; Center for Rare Diseases Cologne, University Hospital of Cologne; University of Cologne
- Avital A. Rodal
- Department of Biology, Brandeis University
- Vincent Timmerman
- Department of Biomedical Sciences, University of Antwerp
- Bruce L. Goode
- Department of Biology, Brandeis University
- Tanja A. Godenschwege
- Department of Biological Sciences, Florida Atlantic University
- Albena Jordanova
- Center for Molecular Neurology, VIB, University of Antwerp
- DOI
- https://doi.org/10.1038/s41467-023-35908-3
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 19
Abstract
Mutations in tRNA ligases, essential components of the translational machinery, are associated with Charcot-Marie-Tooth peripheral neuropathy, but the mechanistic details are not known. The authors report that the tyrosyl-tRNA synthetase is an evolutionary-conserved F-actin organizer, and dysregulation of this function is associated with the disorder.
