1-{(E)-[4-(4-Hydroxyphenyl)butan-2-ylidene]amino}-3-phenylthiourea: crystal structure, Hirshfeld surface analysis and computational study

Abstract

The title thiourea derivative, C17H19N3OS, adopts a U-shaped conformation with the dihedral angle between the terminal aromatic rings being 73.64 (5)°. The major twist in the molecule occurs about the ethane bond with the Ci—Ce—Ce—Cb torsion angle being −78.12 (18)°; i = imine, e = ethane and b = benzene. The configuration about the imine bond is E, the N-bound H atoms lie on opposite sides of the molecule and an intramolecular amine-N—H...N(imine) hydrogen bond is evident. In the molecular packing, hydroxyl-O—H...S(thione) and amine-N—H...O hydrogen bonding feature within a linear, supramolecular chain. The chains are connected into a layer in the ab plane by a combination of methylene-C—H...S(thione), methylene-C—H...O(hydroxyl), methyl-C—H...π(phenyl) and phenyl-C—H...π(hydroxybenzene) interactions. The layers stack without directional interactions between them. The analysis of the calculated Hirshfeld surface highlights the presence of weak methyl-C—H...O(hydroxyl) and H...H interactions in the inter-layer region. Computational chemistry indicates that dispersion energy is the major contributor to the overall stabilization of the molecular packing.

Keywords

• crystal structure
• schiff base
• thiourea
• hydrogen bonding
• hirshfeld surface analysis