Communications Biology (Mar 2022)

Antibody response to oral biofilm is a biomarker for acute coronary syndrome in periodontal disease

  • Mariliis Jaago,
  • Nadežda Pupina,
  • Annika Rähni,
  • Arno Pihlak,
  • Helle Sadam,
  • Nihal Engin Vrana,
  • Juha Sinisalo,
  • Pirkko Pussinen,
  • Kaia Palm

DOI
https://doi.org/10.1038/s42003-022-03122-4
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 10

Abstract

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This study finds that antibodies against antigens present in oral biofilm are potential biomarkers of acute coronary syndrome (ACS), the most severe form of coronary artery disease. By testing antibody response to periodontal pathogens, the authors find that patients with ACS have little or no immune response to a particular antigen epitope.