Intratracheal trimerized nanobody cocktail administration suppresses weight loss and prolongs survival of SARS-CoV-2 infected mice

Kayoko Nagata; Daichi Utsumi; Masamitsu N. Asaka; Ryota Maeda; Kotaro Shirakawa; Yasuhiro Kazuma; Ryosuke Nomura; Yoshihito Horisawa; Yohei Yanagida; Yugo Kawai; Kei Sato; Yutaro Yamaoka; Kei Miyakawa; Akihide Ryo; Yasuhiro Yasutomi; Akihiro Imura; Akifumi Takaori-Kondo

doi:10.1038/s43856-022-00213-5

Communications Medicine (Nov 2022)

Intratracheal trimerized nanobody cocktail administration suppresses weight loss and prolongs survival of SARS-CoV-2 infected mice

Kayoko Nagata,
Daichi Utsumi,
Masamitsu N. Asaka,
Ryota Maeda,
Kotaro Shirakawa,
Yasuhiro Kazuma,
Ryosuke Nomura,
Yoshihito Horisawa,
Yohei Yanagida,
Yugo Kawai,
Kei Sato,
Yutaro Yamaoka,
Kei Miyakawa,
Akihide Ryo,
Yasuhiro Yasutomi,
Akihiro Imura,
Akifumi Takaori-Kondo

Affiliations

Kayoko Nagata: Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University
Daichi Utsumi: Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition
Masamitsu N. Asaka: Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition
Ryota Maeda: COGNANO Inc.
Kotaro Shirakawa: Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University
Yasuhiro Kazuma: Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University
Ryosuke Nomura: Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University
Yoshihito Horisawa: Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University
Yohei Yanagida: Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University
Yugo Kawai: Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University
Kei Sato: Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
Yutaro Yamaoka: Department of Microbiology and Molecular Biodefense Research, Yokohama City University Graduate School of Medicine
Kei Miyakawa: Department of Microbiology and Molecular Biodefense Research, Yokohama City University Graduate School of Medicine
Akihide Ryo: Department of Microbiology and Molecular Biodefense Research, Yokohama City University Graduate School of Medicine
Yasuhiro Yasutomi: Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition
Akihiro Imura: COGNANO Inc.
Akifumi Takaori-Kondo: Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University

DOI: https://doi.org/10.1038/s43856-022-00213-5
Journal volume & issue: Vol. 2, no. 1
pp. 1 – 6

Abstract

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Nagata, Utsumi, Asaka, Maeda et al. describe a nanobody, TP86, that potently neutralizes both BA.1 and BA.2 Omicron SARS-CoV-2 variants, and, when combined with the TP17 nanobody, broadly neutralizes all SARS-CoV-2 variants. This nanobody cocktail also suppresses weight loss and prolongs survival of SARS-CoV-2 infected human ACE2 transgenic mice.

Published in Communications Medicine

ISSN: 2730-664X (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://www.nature.com/commsmed/

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