Hepatoprotective Effects of <i>Pleurotus ostreatus</i> Protein Hydrolysates Yielded by Pepsin Hydrolysis

Liwei Zhang; Yuxiao Lu; Xiaobin Feng; Qinghong Liu; Yuanhui Li; Jiamin Hao; Yanqiong Wang; Yongqiang Dong; Huimin David Wang

doi:10.3390/catal10060595

Catalysts (May 2020)

Hepatoprotective Effects of <i>Pleurotus ostreatus</i> Protein Hydrolysates Yielded by Pepsin Hydrolysis

Liwei Zhang,
Yuxiao Lu,
Xiaobin Feng,
Qinghong Liu,
Yuanhui Li,
Jiamin Hao,
Yanqiong Wang,
Yongqiang Dong,
Huimin David Wang

Affiliations

Liwei Zhang: Department of Microbiology and Immunology, China Agricultural University, Beijing 100193, China
Yuxiao Lu: Department of Environment and Chemical Engineering, Tangshan College, Tangshan 063000, China
Xiaobin Feng: Department of Vegetables, College of Horticulture, China Agriculture University, Beijing 100193, China
Qinghong Liu: Department of Vegetables, College of Horticulture, China Agriculture University, Beijing 100193, China
Yuanhui Li: Department of Vegetables, College of Horticulture, China Agriculture University, Beijing 100193, China
Jiamin Hao: Department of Vegetables, College of Horticulture, China Agriculture University, Beijing 100193, China
Yanqiong Wang: Department of Vegetables, College of Horticulture, China Agriculture University, Beijing 100193, China
Yongqiang Dong: Department of Vegetables, College of Horticulture, China Agriculture University, Beijing 100193, China
Huimin David Wang: Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung 402, Taiwan

DOI: https://doi.org/10.3390/catal10060595
Journal volume & issue: Vol. 10, no. 6
p. 595

Abstract

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Pleurotus ostreatus protein extract (POPE) was prepared by the alkali precipitation method with 0.3% (w/v) NaOH. POPEP-III with a MW of 3000–5000 Da was acquired by pepsin enenzymatic hydrolysis. POPEP-III displayed noteworthy effects of 1,1-diphenyl-2-picrylhydrazyl DPPH and H2O2 scavenging activities, Fe2+ chelating ability, lipid peroxidation inhibition capacity, and metal reducing power. The administration of POPEP-III in mice significantly prevented prior CCl4-induced strengthen serum ALT and AST activities, changing from 365.44 ± 36.87 IU/L to 220.23 ± 22.27 IU/L and 352.52 IU/L to 206.75 ± 17.26 IU/L, respectively (p p p 4-induced oxidative liver histological alteration. The results suggest that POPEP-III can protect the liver from CCl4-induced oxidative damage.

Published in Catalysts

ISSN: 2073-4344 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Chemical technology; Science: Chemistry
Website: https://www.mdpi.com/journal/catalysts

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