Nature Communications (Oct 2021)

Coupled protein synthesis and ribosome-guided piRNA processing on mRNAs

  • Yu H. Sun,
  • Ruoqiao Huiyi Wang,
  • Khai Du,
  • Jiang Zhu,
  • Jihong Zheng,
  • Li Huitong Xie,
  • Amanda A. Pereira,
  • Chao Zhang,
  • Emiliano P. Ricci,
  • Xin Zhiguo Li

DOI
https://doi.org/10.1038/s41467-021-26233-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 19

Abstract

Read online

Ribosome can mediate piRNA biogenesis from long non-coding RNAs following translation of the short open reading frames. Here the authors show that 80S ribosome also guides piRNA production from 3’ UTR of protein-coding genes after translation of long open reading frames, indicating a general piRNA biogenesis mechanism regardless of their precursor ORF length.