Medicina v Kuzbasse (Dec 2023)
THE EFFECTIVENESS OF THE USE OF THE VITAMIN AND MINERAL COMPLEX FOR THE CORRECTION OF WATER-SALT METABOLISM IN CHRONIC FLUORIDE INTOXICATION (EXPERIMENTAL STUDIES)
Abstract
Object of study. To solve the tasks set, 3 series of experiments were carried out on white non-linear male rats, weighing 200-250 g, (n = 90), divided into 3 groups of 30 rats: control; experimental, with fluoride intoxication, which was modeled by free access of animals to an aqueous solution of sodium fluoride (NaF) at a concentration of 10 mg/l (daily dose of 1.2 mg/kg of body weight); a group of rats with correction, daily (12 weeks) on the background of fluoride intoxication, receiving oral (300 mg/kg) vitamin and mineral supplement «Golden Ball». The rats were kept under standard vivarium conditions on a normal food ration with the water regime and alternating daily illumination. The aim of the research. Is to study the effectiveness of the use of a vitamin-mineral complex on water-salt metabolism in conditions of experimental chronic fluoride intoxication of the body. Materials and methods. When modeling fluoride intoxication, the efficiency of using the Golden Ball vitamin-mineral complex for correcting the parameters of water-salt and mineral homeostasis was evaluated. The experiments were carried out in groups of white non-linear rats with correction (appointment of the vitamin-mineral complex) and in the experimental group without prescription. The biochemical parameters of blood plasma and urine were studied after 1, 3, 6, 9, 12 weeks. Changes in the level of F, Na+, K+, Mg2+, Ca2+, Рneorg., urea, creatinine were studied. Daily diuresis was determined by the metric method in exchange cells for laboratory rats. The partial functions of the kidneys were calculated. Results. In the dynamics of experimental chronic fluoride intoxication, it was shown that the administration of the Golden Ball vitamin-mineral complex contributes to the increasing excretion of excess F in the urine in rats against the background of maintaining the physiological level of Ca2+, Mg2+, Pneorg. in blood plasma. The corrective effect of the drug on water-salt homeostasis and filtration-reabsorption processes in the kidneys was determined. Conclusion. The results obtained are of practical importance in the development of effective methods of timely organ-protective prevention and allow us to recommend the prescription of the drug «Golden Ball» as one of the means of early symptomatic correction of pathological disorders of the water-salt balance, depending on the severity and duration of fluoride intoxication. The use of the studied vitamin-mineral complex enhances the binding and excretion of F with urine, reduces its toxic effect on the body.
