Intrafusal-fiber LRP4 for muscle spindle formation and maintenance in adult and aged animals

Rangjuan Cao; Peng Chen; Hongsheng Wang; Hongyang Jing; Hongsheng Zhang; Guanglin Xing; Bin Luo; Jinxiu Pan; Zheng Yu; Wen-Cheng Xiong; Lin Mei

doi:10.1038/s41467-023-36454-8

Nature Communications (Feb 2023)

Intrafusal-fiber LRP4 for muscle spindle formation and maintenance in adult and aged animals

Rangjuan Cao,
Peng Chen,
Hongsheng Wang,
Hongyang Jing,
Hongsheng Zhang,
Guanglin Xing,
Bin Luo,
Jinxiu Pan,
Zheng Yu,
Wen-Cheng Xiong,
Lin Mei

Affiliations

Rangjuan Cao: Department of Neurosciences, School of Medicine, Case Western Reserve University
Peng Chen: Department of Neurosciences, School of Medicine, Case Western Reserve University
Hongsheng Wang: Department of Neurosciences, School of Medicine, Case Western Reserve University
Hongyang Jing: Department of Neurosciences, School of Medicine, Case Western Reserve University
Hongsheng Zhang: Department of Neurosciences, School of Medicine, Case Western Reserve University
Guanglin Xing: Department of Neurosciences, School of Medicine, Case Western Reserve University
Bin Luo: Department of Neurosciences, School of Medicine, Case Western Reserve University
Jinxiu Pan: Department of Neurosciences, School of Medicine, Case Western Reserve University
Zheng Yu: Department of Neurosciences, School of Medicine, Case Western Reserve University
Wen-Cheng Xiong: Department of Neurosciences, School of Medicine, Case Western Reserve University
Lin Mei: Department of Neurosciences, School of Medicine, Case Western Reserve University

DOI: https://doi.org/10.1038/s41467-023-36454-8
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 17

Abstract

Read online

Muscle spindles sense muscle tension to coordinate body movement. This paper reveals a mechanism of spindle formation and maintenance and to better understanding changes in movement in muscle disorders and ageing.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal