Fluorinated Analogs of Malachite Green: Synthesis and Toxicity

Abstract

A series of fluorinated analogs of malachite green (MG) have been synthesizedand their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell lineexamined. The toxicity profiles were found to be different for these two species. Twoanalogs, one with 2,4-difluoro substitution and the other with 2-fluoro substitution seem tobe the most promising analogs because they showed the lowest toxicity to the human cells.

Keywords

• Malachite Green
• Malachite Green analogs
• Bathochromic shift
• Toxicity
• Saccharomyces cerevisiae
• human ovarian epithelial cells.