Anti-Müllerian hormone: Predictor of premature ovarian insufficiency in Egyptian women with autoimmune thyroiditis

Abstract

Background: Menopause associated with hormone-sensitive co-morbidity such as breast cancer, endometrial cancer, osteoporosis, and cardiovascular disease. Autoimmunity is one of the leading causes of primary ovarian insufficiency (POI). Thyroiditis is the most common associated autoimmune disease. The aim of our study was to estimate the role of Anti-Müllerian hormone (AMH) as predictor of POI among women with autoimmune thyroiditis and to assess the prevalence of thyroid dysfunction in different menopausal stages. Method of study: A cross-sectional study included 200 unrelated women with autoimmune thyroiditis classified according to menopausal stages, anti-thyroglobulin (anti-TG), anti-thyroid peroxidase (anti-TPO) and AMH were measured. Results: In postmenopausal women (natural and premature) AMH levels were significantly lower. Linear regression analysis test explored that AMH levels were independently correlated with age, anti TG and ovarian volume. The prevalence of subclinical hypothyroidism (SCHT) was the highest among thyroid disorders. Conclusion: AMH levels were decreased in both natural and premature postmenopausal women and could be used as predictor of menopause among women with autoimmune thyroiditis. Keywords: Anti-thyroglobulin, Anti-thyroid peroxidase, Postmenopausal