Membrane cholesterol mediates the cellular effects of monolayer graphene substrates

Kristina E. Kitko; Tu Hong; Roman M. Lazarenko; Da Ying; Ya-Qiong Xu; Qi Zhang

doi:10.1038/s41467-018-03185-0

Nature Communications (Feb 2018)

Membrane cholesterol mediates the cellular effects of monolayer graphene substrates

Kristina E. Kitko,
Tu Hong,
Roman M. Lazarenko,
Da Ying,
Ya-Qiong Xu,
Qi Zhang

Affiliations

Kristina E. Kitko: Department of Pharmacology, Vanderbilt University
Tu Hong: Department of Electrical Engineering and Computer Science, Vanderbilt University
Roman M. Lazarenko: Department of Pharmacology, Vanderbilt University
Da Ying: Department of Electrical Engineering and Computer Science, Vanderbilt University
Ya-Qiong Xu: Program in Interdisciplinary Materials Science, Vanderbilt University
Qi Zhang: Department of Pharmacology, Vanderbilt University

DOI: https://doi.org/10.1038/s41467-018-03185-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 17

Abstract

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Understanding the biological role of graphene in eukaryotic cells is essential for future biomedicine applications. Here, the authors investigate the interaction of neurons and fibroblasts with graphene substrates, which increase cell membrane cholesterol and potentiate neurotransmitter release and receptor signaling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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