A Convenient Synthesis of Amino Acid Methyl Esters

Abstract

A series of amino acid methyl ester hydrochlorides were prepared in good toexcellent yields by the room temperature reaction of amino acids with methanol in thepresence of trimethylchlorosilane. This method is not only compatible with natural aminoacids, but also with other aromatic and aliphatic amino acids.

Keywords

• Amino acid methyl ester hydrochlorides
• amino acids
• trimethylchlorosilane
• esterification