Individual-level functional connectivity predicts cognitive control efficiency
Benjamin L. Deck,
Apoorva Kelkar,
Brian Erickson,
Fareshte Erani,
Eric McConathey,
Daniela Sacchetti,
Olufunsho Faseyitan,
Roy Hamilton,
John D. Medaglia
Affiliations
Benjamin L. Deck
Department of Psychological and Brain Sciences, Drexel University, 3201 Chestnut Street, Philadelphia, 19104, PA, USA
Apoorva Kelkar
Department of Psychological and Brain Sciences, Drexel University, 3201 Chestnut Street, Philadelphia, 19104, PA, USA
Brian Erickson
Department of Psychological and Brain Sciences, Drexel University, 3201 Chestnut Street, Philadelphia, 19104, PA, USA
Fareshte Erani
Department of Psychological and Brain Sciences, Drexel University, 3201 Chestnut Street, Philadelphia, 19104, PA, USA
Eric McConathey
Department of Neurology, The University of Pennsylvania: Perelman School of Medicine, 3400 Civic Center Blvd, Philadelphia, 19104, PA, USA
Daniela Sacchetti
Department of Neurology, The University of Pennsylvania: Perelman School of Medicine, 3400 Civic Center Blvd, Philadelphia, 19104, PA, USA
Olufunsho Faseyitan
Department of Neurology, The University of Pennsylvania: Perelman School of Medicine, 3400 Civic Center Blvd, Philadelphia, 19104, PA, USA
Roy Hamilton
Department of Neurology, The University of Pennsylvania: Perelman School of Medicine, 3400 Civic Center Blvd, Philadelphia, 19104, PA, USA
John D. Medaglia
Department of Psychological and Brain Sciences, Drexel University, 3201 Chestnut Street, Philadelphia, 19104, PA, USA; Department of Neurology, The University of Pennsylvania: Perelman School of Medicine, 3400 Civic Center Blvd, Philadelphia, 19104, PA, USA; Corresponding author at: Department of Neurology, The University of Pennsylvania: Perelman School of Medicine, 3400 Civic Center Blvd, Philadelphia, 19104, PA, USA.
Cognitive control (CC) is essential for problem-solving in everyday life, and CC-related deficits occur alongside costly and debilitating disorders. The tri-partite model suggests that CC comprises multiple behaviors, including switching, inhibiting, and updating. Activity within the fronto-parietal control network B (FPCN-B), the dorsal attention network (DAN), the cingulo-opercular network (CON), and the lateral default-mode network (L-DMN) is related to switching and inhibiting behaviors. However, our understanding of how these brain regions interact to bring about cognitive switching and inhibiting in individuals is unclear. In the current study, subjects performed two in-scanner tasks that required switching and inhibiting. We used support vector regression (SVR) models containing individually-estimated functional connectivity between the FPCN-B, DAN, CON and L-DMN to predict switching and inhibiting behaviors. We observed that: inter-network connectivity can predict inhibiting and switching behaviors in individuals, and the L-DMN plays a role in switching and inhibiting behaviors. Therefore, individually estimated inter-network connections are markers of CC behaviors, and CC behaviors may arise due to interactions between a set of networks.
