Comprehensive Review on Medicinal Applications of Coumarin-Derived Imine–Metal Complexes
Siddappa A. Patil,
Vishal Kandathil,
Anjali Sobha,
Sasidhar B. Somappa,
Max R. Feldman,
Alejandro Bugarin,
Shivaputra A. Patil
Affiliations
Siddappa A. Patil
Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Bangalore 562112, India
Vishal Kandathil
Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Bangalore 562112, India
Anjali Sobha
Organic Chemistry Section, Chemical Sciences & Technology Division, National Institute for Interdisciplinary Science and Technology (CSIR), Thiruvananthapuram 695019, India
Sasidhar B. Somappa
Organic Chemistry Section, Chemical Sciences & Technology Division, National Institute for Interdisciplinary Science and Technology (CSIR), Thiruvananthapuram 695019, India
Max R. Feldman
Department of Chemistry & Physics, Florida Gulf Coast University, 10501 FGCU Boulevard South, Fort Myers, FL 33965, USA
Alejandro Bugarin
Department of Chemistry & Physics, Florida Gulf Coast University, 10501 FGCU Boulevard South, Fort Myers, FL 33965, USA
Shivaputra A. Patil
Pharmaceutical Sciences Department, College of Pharmacy, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
Coumarins are fused six-membered oxygen-containing benzoheterocycles that join two synthetically useful rings: α-pyrone and benzene. A survey of the literature shows that coumarins and their metal complexes have received great interest from synthetic chemists, medicinal scientists, and pharmacists due to their wide spectrum of biological applications. For instance, coumarin and its derivatives have been used as precursors to prepare a large variety of medicinal agents. Likewise, coumarin-derived imine–metal complexes have been found to display a variety of therapeutic applications, such as antibacterial, antifungal, anticancer, antioxidant, anthelmintic, pesticidal, and nematocidal activities. This review highlights the current synthetic methodologies and known bioactivities of coumarin-derived imine–metal complexes that make this molecule a more attractive scaffold for the discovery of newer drugs.
