Endocrinology and Metabolism (Jun 2020)
Diagnosis and Treatment of Growth Hormone Deficiency: A Position Statement from Korean Endocrine Society and Korean Society of Pediatric Endocrinology
- Jung Hee Kim,
- Hyun Wook Chae,
- Sang Ouk Chin,
- Cheol Ryong Ku,
- Kyeong Hye Park,
- Dong Jun Lim,
- Kwang Joon Kim,
- Jung Soo Lim,
- Gyuri Kim,
- Yun Mi Choi,
- Seong Hee Ahn,
- Min Ji Jeon,
- Yul Hwangbo,
- Ju Hee Lee,
- Bu Kyung Kim,
- Yong Jun Choi,
- Kyung Ae Lee,
- Seong-Su Moon,
- Hwa Young Ahn,
- Hoon Sung Choi,
- Sang Mo Hong,
- Dong Yeob Shin,
- Ji A Seo,
- Se Hwa Kim,
- Seungjoon Oh,
- Sung Hoon Yu,
- Byung Joon Kim,
- Choong Ho Shin,
- Sung-Woon Kim,
- Chong Hwa Kim,
- Eun Jig Lee
Affiliations
- Jung Hee Kim
- Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
- Hyun Wook Chae
- Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea
- Sang Ouk Chin
- Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea
- Cheol Ryong Ku
- Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
- Kyeong Hye Park
- Division of Endocrinology and Metabolism, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Korea
- Dong Jun Lim
- Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
- Kwang Joon Kim
- Division of Geriatrics, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
- Jung Soo Lim
- Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea
- Gyuri Kim
- Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
- Yun Mi Choi
- Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea
- Seong Hee Ahn
- Department of Endocrinology, Inha University School of Medicine, Incheon, Korea
- Min Ji Jeon
- Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
- Yul Hwangbo
- Department of Internal Medicine, National Cancer Center, Goyang, Korea
- Ju Hee Lee
- Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea
- Bu Kyung Kim
- Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea
- Yong Jun Choi
- Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Korea
- Kyung Ae Lee
- Division of Endocrinology and Metabolism, Department of Internal Medicine, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea
- Seong-Su Moon
- Department of Internal Medicine, Dongguk University College of Medicine, Gyeongju, Korea
- Hwa Young Ahn
- Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea
- Hoon Sung Choi
- Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea
- Sang Mo Hong
- Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea
- Dong Yeob Shin
- Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
- Ji A Seo
- Division of Endocrinology, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea
- Se Hwa Kim
- Department of Internal Medicine, International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon, Korea
- Seungjoon Oh
- Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea
- Sung Hoon Yu
- Department of Endocrinology and Metabolism, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea
- Byung Joon Kim
- Division of Endocrinology, Department of Internal Medicine, Gachon University College of Medicine, Incheon, Korea
- Choong Ho Shin
- Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
- Sung-Woon Kim
- Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea
- Chong Hwa Kim
- Division of Endocrinology and Metabolism, Department of Internal Medicine, Sejong General Hospital, Bucheon, Korea
- Eun Jig Lee
- Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
- DOI
- https://doi.org/10.3803/EnM.2020.35.2.272
- Journal volume & issue
-
Vol. 35,
no. 2
pp. 272 – 287
Abstract
Growth hormone (GH) deficiency is caused by congenital or acquired causes and occurs in childhood or adulthood. GH replacement therapy brings benefits to body composition, exercise capacity, skeletal health, cardiovascular outcomes, and quality of life. Before initiating GH replacement, GH deficiency should be confirmed through proper stimulation tests, and in cases with proven genetic causes or structural lesions, repeated GH stimulation testing is not necessary. The dosing regimen of GH replacement therapy should be individualized, with the goal of minimizing side effects and maximizing clinical improvements. The Korean Endocrine Society and the Korean Society of Pediatric Endocrinology have developed a position statement on the diagnosis and treatment of GH deficiency. This position statement is based on a systematic review of evidence and expert opinions.
Keywords
