Atomic structure of the human herpesvirus 6B capsid and capsid-associated tegument complexes

Yibo Zhang; Wei Liu; Zihang Li; Vinay Kumar; Ana L. Alvarez-Cabrera; Emily C. Leibovitch; Yanxiang Cui; Ye Mei; Guo-Qiang Bi; Steve Jacobson; Z. Hong Zhou

doi:10.1038/s41467-019-13064-x

Nature Communications (Nov 2019)

Atomic structure of the human herpesvirus 6B capsid and capsid-associated tegument complexes

Yibo Zhang,
Wei Liu,
Zihang Li,
Vinay Kumar,
Ana L. Alvarez-Cabrera,
Emily C. Leibovitch,
Yanxiang Cui,
Ye Mei,
Guo-Qiang Bi,
Steve Jacobson,
Z. Hong Zhou

Affiliations

Yibo Zhang: Center for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, and School of Life Sciences, University of Science and Technology of China (USTC)
Wei Liu: Center for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, and School of Life Sciences, University of Science and Technology of China (USTC)
Zihang Li: California NanoSystems Institute, University of California, Los Angeles (UCLA)
Vinay Kumar: California NanoSystems Institute, University of California, Los Angeles (UCLA)
Ana L. Alvarez-Cabrera: California NanoSystems Institute, University of California, Los Angeles (UCLA)
Emily C. Leibovitch: Viral Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH)
Yanxiang Cui: California NanoSystems Institute, University of California, Los Angeles (UCLA)
Ye Mei: State Key Laboratory of Precision Spectroscopy, School of Physics and Electronic Science, East China Normal University (ECNU)
Guo-Qiang Bi: Center for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, and School of Life Sciences, University of Science and Technology of China (USTC)
Steve Jacobson: Viral Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH)
Z. Hong Zhou: California NanoSystems Institute, University of California, Los Angeles (UCLA)

DOI: https://doi.org/10.1038/s41467-019-13064-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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Human Herpesvirus 6B (HHV-6) can cause fever, diarrhea and roseola rash. Here the authors present a cryoEM approach to image crude, minimally purified virus samples and employ it to determine the atomic structures of HHV-6B capsid and capsid-associated tegument protein complexes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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