Nature Communications (Nov 2022)
Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin
- Hyosung Kim,
- Kun Leng,
- Jinhee Park,
- Alexander G. Sorets,
- Suil Kim,
- Alena Shostak,
- Rebecca J. Embalabala,
- Kate Mlouk,
- Ketaki A. Katdare,
- Indigo V. L. Rose,
- Sarah M. Sturgeon,
- Emma H. Neal,
- Yan Ao,
- Shinong Wang,
- Michael V. Sofroniew,
- Jonathan M. Brunger,
- Douglas G. McMahon,
- Matthew S. Schrag,
- Martin Kampmann,
- Ethan S. Lippmann
Affiliations
- Hyosung Kim
- Department of Chemical and Biomolecular Engineering, Vanderbilt University
- Kun Leng
- Institute for Neurodegenerative Diseases, University of California, San Francisco
- Jinhee Park
- Department of Molecular Physiology and Biophysics, Vanderbilt University
- Alexander G. Sorets
- Department of Biomedical Engineering, Vanderbilt University
- Suil Kim
- Vanderbilt Brain Institute, Vanderbilt University
- Alena Shostak
- Department of Neurology, Vanderbilt University Medical Center
- Rebecca J. Embalabala
- Vanderbilt Brain Institute, Vanderbilt University
- Kate Mlouk
- Vanderbilt Brain Institute, Vanderbilt University
- Ketaki A. Katdare
- Vanderbilt Brain Institute, Vanderbilt University
- Indigo V. L. Rose
- Institute for Neurodegenerative Diseases, University of California, San Francisco
- Sarah M. Sturgeon
- Department of Chemical and Biomolecular Engineering, Vanderbilt University
- Emma H. Neal
- Department of Chemical and Biomolecular Engineering, Vanderbilt University
- Yan Ao
- Department of Neurobiology, University of California, Los Angeles
- Shinong Wang
- Department of Neurobiology, University of California, Los Angeles
- Michael V. Sofroniew
- Department of Neurobiology, University of California, Los Angeles
- Jonathan M. Brunger
- Department of Biomedical Engineering, Vanderbilt University
- Douglas G. McMahon
- Vanderbilt Brain Institute, Vanderbilt University
- Matthew S. Schrag
- Vanderbilt Brain Institute, Vanderbilt University
- Martin Kampmann
- Institute for Neurodegenerative Diseases, University of California, San Francisco
- Ethan S. Lippmann
- Department of Chemical and Biomolecular Engineering, Vanderbilt University
- DOI
- https://doi.org/10.1038/s41467-022-34412-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Inflammation of brain endothelial cells is seen in neurodegenerative conditions and in aging. Here the authors examine the role of astrocytes in blood brain barrier function using an iPSC-derived cell co-culture model.
