3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors

Abstract

The brain extracellular matrix (ECM) is altered in brain tumors, but its role in cancer progression and drug sensitivity are difficult to study. Here the authors develop a 3D bioengineered brain tissue model using patient-derived samples and tunable brain-derived ECM to examine the interplay between cells and the ECM.