Nature Communications (Sep 2022)
Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis
- Benedikt Jaeger,
- Jonas Christian Schupp,
- Linda Plappert,
- Oliver Terwolbeck,
- Nataliia Artysh,
- Gian Kayser,
- Peggy Engelhard,
- Taylor Sterling Adams,
- Robert Zweigerdt,
- Henning Kempf,
- Stefan Lienenklaus,
- Wiebke Garrels,
- Irina Nazarenko,
- Danny Jonigk,
- Malgorzata Wygrecka,
- Denise Klatt,
- Axel Schambach,
- Naftali Kaminski,
- Antje Prasse
Affiliations
- Benedikt Jaeger
- Fraunhofer Institute for Toxicology and Experimental Medicine
- Jonas Christian Schupp
- German Center for Lung Research, BREATH
- Linda Plappert
- Fraunhofer Institute for Toxicology and Experimental Medicine
- Oliver Terwolbeck
- Fraunhofer Institute for Toxicology and Experimental Medicine
- Nataliia Artysh
- Fraunhofer Institute for Toxicology and Experimental Medicine
- Gian Kayser
- Institute of Surgical Pathology, University Medical Center
- Peggy Engelhard
- Department of Pneumology, University Medical Center
- Taylor Sterling Adams
- Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine
- Robert Zweigerdt
- Leibniz Research Laboratories for Biotechnology and Artificial Organs, Hannover Medical School
- Henning Kempf
- Leibniz Research Laboratories for Biotechnology and Artificial Organs, Hannover Medical School
- Stefan Lienenklaus
- Institute for Laboratory Animal Science, Hannover Medical School
- Wiebke Garrels
- Institute for Laboratory Animal Science, Hannover Medical School
- Irina Nazarenko
- Institute for Infection Prevention and Hospital Epidemiology, Medical Center - University of Freiburg
- Danny Jonigk
- German Center for Lung Research, BREATH
- Malgorzata Wygrecka
- Department of Biochemistry, Faculty of Medicine, Justus Liebig University
- Denise Klatt
- Institute of Experimental Hematology, Hannover Medical School
- Axel Schambach
- Institute of Experimental Hematology, Hannover Medical School
- Naftali Kaminski
- Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine
- Antje Prasse
- Fraunhofer Institute for Toxicology and Experimental Medicine
- DOI
- https://doi.org/10.1038/s41467-022-33193-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
The functional role of airway basal cells has not been comprehensively studied in idiopathic pulmonary fibrosis (IPF). Here, the authors show that airway basal cells of IPF patients display a distinct phenotype, are profibrotic if transplanted to mice and that fibrosis can be ameliorated by Src iinhibitors.
