Nature Communications (Nov 2019)
Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control
- Fredrik Barrenas,
- Kevin Raehtz,
- Cuiling Xu,
- Lynn Law,
- Richard R. Green,
- Guido Silvestri,
- Steven E. Bosinger,
- Andrew Nishida,
- Qingsheng Li,
- Wuxun Lu,
- Jianshui Zhang,
- Matthew J. Thomas,
- Jean Chang,
- Elise Smith,
- Jeffrey M. Weiss,
- Reem A. Dawoud,
- George H. Richter,
- Anita Trichel,
- Dongzhu Ma,
- Xinxia Peng,
- Jan Komorowski,
- Cristian Apetrei,
- Ivona Pandrea,
- Michael Gale
Affiliations
- Fredrik Barrenas
- Department of Microbiology, University of Washington
- Kevin Raehtz
- Division of Infectious Diseases, Department of Medicine, University of Pittsburgh
- Cuiling Xu
- Department of Pathology, School of Medicine, University of Pittsburgh
- Lynn Law
- Department of Immunology, University of Washington
- Richard R. Green
- Department of Immunology, University of Washington
- Guido Silvestri
- Department of Pathology & Laboratory Medicine, Emory University
- Steven E. Bosinger
- Department of Pathology & Laboratory Medicine, Emory University
- Andrew Nishida
- Department of Microbiology, University of Washington
- Qingsheng Li
- Nebraska Center for Virology, School of Biological Sciences, University of Nebraska-Lincoln
- Wuxun Lu
- Nebraska Center for Virology, School of Biological Sciences, University of Nebraska-Lincoln
- Jianshui Zhang
- Nebraska Center for Virology, School of Biological Sciences, University of Nebraska-Lincoln
- Matthew J. Thomas
- Department of Immunology, University of Washington
- Jean Chang
- Department of Immunology, University of Washington
- Elise Smith
- Department of Immunology, University of Washington
- Jeffrey M. Weiss
- Department of Microbiology, University of Washington
- Reem A. Dawoud
- Department of Pathology & Laboratory Medicine, Emory University
- George H. Richter
- Department of Pathology, School of Medicine, University of Pittsburgh
- Anita Trichel
- Divison of Laboratory Animal Resources, University of Pittsburgh
- Dongzhu Ma
- Department of Orthopedic Surgery, University of Pittsburgh
- Xinxia Peng
- Department of Molecular Biomedical Sciences, North Carolina State University
- Jan Komorowski
- Department of Cell and Molecular Biology, Uppsala University
- Cristian Apetrei
- Division of Infectious Diseases, Department of Medicine, University of Pittsburgh
- Ivona Pandrea
- Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh
- Michael Gale
- Department of Immunology, University of Washington
- DOI
- https://doi.org/10.1038/s41467-019-12987-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Here, the authors compare gene expression signatures in rectal tissues of African green monkeys (AGMs) and rhesus macaques (RMs) acutely infected with simian immunodeficiency virus and find that AGMs rapidly activate and maintain evolutionarily conserved regenerative wound healing mechanisms.
