Nature Communications (May 2017)

Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis

  • Yuqi Guo,
  • Chengzhi Xie,
  • Xiyan Li,
  • Jian Yang,
  • Tao Yu,
  • Ruohan Zhang,
  • Tianqing Zhang,
  • Deepak Saxena,
  • Michael Snyder,
  • Yingjie Wu,
  • Xin Li

DOI
https://doi.org/10.1038/ncomms15621
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

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Bone loss is common in patients with diabetes, but the underlying molecular and cellular mechanisms are unclear. Here the authors show high succinate levels in mice with type 2 diabetes and that succinate can signal through succinate receptor 1 on osteoclasts to induce bone resorption.