3D RNA-scaffolded wireframe origami

Molly F. Parsons; Matthew F. Allan; Shanshan Li; Tyson R. Shepherd; Sakul Ratanalert; Kaiming Zhang; Krista M. Pullen; Wah Chiu; Silvi Rouskin; Mark Bathe

doi:10.1038/s41467-023-36156-1

Nature Communications (Jan 2023)

3D RNA-scaffolded wireframe origami

Molly F. Parsons,
Matthew F. Allan,
Shanshan Li,
Tyson R. Shepherd,
Sakul Ratanalert,
Kaiming Zhang,
Krista M. Pullen,
Wah Chiu,
Silvi Rouskin,
Mark Bathe

Affiliations

Molly F. Parsons: Department of Biological Engineering, Massachusetts Institute of Technology
Matthew F. Allan: Department of Biological Engineering, Massachusetts Institute of Technology
Shanshan Li: Department of Bioengineering, Stanford University
Tyson R. Shepherd: Department of Biological Engineering, Massachusetts Institute of Technology
Sakul Ratanalert: Department of Biological Engineering, Massachusetts Institute of Technology
Kaiming Zhang: Department of Bioengineering, Stanford University
Krista M. Pullen: Department of Biological Engineering, Massachusetts Institute of Technology
Wah Chiu: Department of Bioengineering, Stanford University
Silvi Rouskin: Department of Microbiology, Harvard Medical School
Mark Bathe: Department of Biological Engineering, Massachusetts Institute of Technology

DOI: https://doi.org/10.1038/s41467-023-36156-1
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 14

Abstract

Read online

Hybrid nucleic acid origami has potential for biomedical delivery of mRNA and fabrication of artificial ribozymes. Here, the authors use chemical footprinting and cryo-electron microscopy to reveal insights into nucleic acid origami used to fold messenger and ribosomal RNA into 3D polyhedral structures.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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